Wednesday, 19th February Lorne Infection and Immunity 2020

Paul Hertzog, Hudson Institute of Medical Research

• Proteolytic enzymes in host red blood cell invasion and egress by the malaria parasite - Michael Blackman
• Death, Destruction and Inflammasome Activation in Tuberculosis Pathogenesis - Anna Coussens
• Elucidating the molecular basis for chronic carriage of Salmonella - Ian Henderson
• Inhibition of PrfA activity restricts L. monocytogenes to spacious vacuoles and licenses macrophages to eliminate high intracellular bacterial loads - Antje Blumenthal
• Understanding and preventing pathogenic bacteria from colonising host surfaces - Jason Paxman
• Flaviviruses target HSP90 to broadly inhibit JAK/STAT signalling; a mechanism leading to ZIKV dysregulation of neural stem cell differentiation. - Justin A Roby
• Imaging the interaction of bacterial pore-forming toxins with host membranes - Seong Hoong Chow
• Unravelling mechanisms of TLR-inducible mitochondrial fission and fission-mediated antimicrobial responses in macrophages - Syeda Farhana Afroz

• The good, the bad and the ugly: The microbiome and its role in health and disease - Georgina Hold
• Identification of a novel target for host-directed therapy against tuberculosis - Katharina Ronacher
• Targeting tuft cells and innate lymphoid cells in gastric Cancer - Ryan O'Keefe
• Unexpected role of dying cell disassembly in cell clearance and immunity - Ivan Poon
• Regulation of T cell immunity to chronic infections and immunotherapy - David Brooks

• Tuberculosis Traps: dissecting the mechanisms of Mycobacterium tuberculosis induced NETosis in human neutrophils - Erya Ni
• Non-canonical STAT3 Ser phosphorylation by TBK-1 is critically required for TLR4-induced metabolic reprogramming - Hassan HA Albargy
• Discovery of the molecular machinery regulating antigen presentation of bacterial metabolites by MR1 - Hui Jing Lim
• The burden of rotavirus disease and genotypic diversity in children and adults in the vaccine-era in Australia - Celeste M Donato
• Combating diarrhoeal infections by targeting secreted toxins from pathogenic Escherichia coli strains - Akila Pilapitiya
• The story of a rogue B cell clone in Hepatitis C virus-associated cryoglobulinemic vasculitis - Clara C Young
• Caspase-8 transcriptional activity licences IFNγ- and LPS-induced macrophage killing - Daniel S Simpson
• In Vivo Dual RNA-Seq Analysis Reveals the Basis for Differential Tissue Tropism of Clinical Isolates of Streptococcus pneumoniae - Vikrant Minhas
• Antibody titres to potential NTHi vaccine candidates are reduced in Australian Aboriginal otitis prone children but do not change depending on remoteness - Sharon Clark
• Disparate functions of mucin 1 (MUC1) during bacterial infections and inflammation.   - Poshmaal Dr Dhar

Virus: SARS-CoV-2  (Severe Acute Respiratory Syndrome Coronavirus 2) (designated by Coronavirus Study Group (CSG) of the International Committee on Taxonomy of Viruses)

Disease: COVID-19 (CoronaVirus Disease, 2019) (designated by WHO)

• GSDME and HOOK3 do not regulate the apoptotic cell disassembly in both Jurkat T cells and monocytic THP1 cells - BO SHI
• Entry strategies of respiratory viruses into cells and control of replication by IFITM antiviral molecules - Tina Meischel
• Cannabidiol is remarkably active as a Gram-positive antibiotic - Mark A. T. Blaskovich
• Lack of MHC II ubiquitination impairs dendritic cell function - Kayla R Wilson
• The Salmonella effector SseK3 targets small Rab GTPases and inhibits host protein secretion - Jiyao Gan
• Understanding innate immune interactions in fungal infections - Francios AB Olivier
• The search for evolutionarily robust antibacterials: fragment-based development of inhibitors of a key mediator of bacterial virulence - Tony Wang
• Investigating the link between antifungal-induced cell membrane stress and proteostasis in the human yeast pathogen Candida albicans - Ka Pui Sharon Yau
• Carbapenem sensitivity vs resitance to gram negative organisms:  Clinical inpatient outcomes from a single center tertiary care hospital in low and middle income country (LMIC) - Mir Ibrahim Sajid
• Large genomic deletions in Legionella pneumophila identify new genes influencing intracellular replication and lung infection - Raissa Wibawa
• The E3 ubiquitin ligase, RNF41, regulates the dendritic cell receptor, Clec9A, via the ER-Associated Degradation pathway - Nicole Michael
• The role of immune cells in contact hypersensitivity - Rohit Jain
• The neonatal Fc receptor regulates the presentation of antigens targeted to the dendritic cell receptor DEC205 - Christophe Macri
• Synergistic and antagonistic interactions between Streptococcus pneumoniae and Respiratory Syncytial Virus in an infant mouse model - Sam Manna
• The colon microcosm: a novel in vitro model to study Candida albicans colonisation of the human colon - Megan D Lenardon
• Beyond damage repair: Cell envelope stress resistance in Haemophilus influenzae as a determinant of successful host interactions - Ulrike Kappler
• The role of RHIM proteins in bacterial gut infection - Vik Ven Eng
• β-adrenergic regulation of macrophage immunometabolism - Amanda L Peterson
• Metformin enhances macrophage clearance of Leishmania mexicana - Katrina J Binger
• Success and failure of adoptive T cell therapy against cancer - Christina Scheffler
• Linking cell metabolism and host defense - O-GlcNAcylation in dendritic cells - Ilknur Spring
• Breaking antibiotic resistance in Streptococcal pneumonia - Christopher McDevitt
• Monophasic Salmonella Typhimurium strains exhibit increased replication capacity in human macrophages by modulating intracellular host responses - Rebecca L Ambrose
• Transcriptomics reveal the mechanisms of host-pathogen-drug interactions during polymyxin treatment for Acinetobacter baumannii infection of human lung epithelial cells - Mengyao Li
• Mechanisms governing STING-induced NF-κB responses - Dominic De Nardo
• Salmonella Typhimurium induces cIAP1 degradation in macrophages in a SPI-1 dependent manner - Madeleine Wemyss
• Outer membrane vesicles generated via different mechanisms of biogenesis have altered antimicrobial functions.  - Lauren Zavan
• Identification of estrogen receptor modulators as inhibitors of flavivirus infection - Nicholas S Eyre
• Seroprevalence of six arboviruses among Papua New Guinea Defence Force personnel - Wenjun Liu
• Bacterial outer membrane vesicles induce mitochondrial dysfunction and intrinsic apoptosis-mediated inflammation - Pankaj Deo
• Structural Elucidation of Viral Antagonism of Innate Immunity: The STAT1 Interface - Gregory Moseley
• Drug susceptibility profiling of Australian Burkholderia species as models for developing melioidosis therapeutics  - Anna Amiss
• Impact of microbial short chain fatty acids on intracellular pathogens                                                                            - Gilu Abraham
• Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. - Sofiya Tsimbalyuk
• Wollamide cyclic hexapeptides synergise with tuberculosis antibiotics in inhibiting replication of Mycobacterium tuberculosis - Rachel F Rollo
• Targeting host factors in infections: new role of FBXO11 in PVL-mediated cell death - Yusun Jeon
• Examination of the mucosa-associated microbiota in a murine IBD model via an ex vivo combination of microbial-culture with metagenomic sequencing (MC-MGS) - Jing Jie Teh
• The structural biology of FabG homologs from multi-drug resistant Acinetobacter baumannii; targets for antimicrobial drug design. - Emily M Cross
• The role of macrophages in aiding apoptotic cell fragmentation - Jascinta Santavanond
• Zika virus infection of first trimester human placental explants and primary villous cytotrophoblasts - Kylie H Van der Hoek
• Characterisation of Klebsiella pneumoniae outer membrane vesicles and their interaction with the innate immune system - Isabella I Stuart
• A novel segmental intrabronchial delivery technique for the study of idiopathic pulmonary fibrosis in mice - Giulia Iacono
• Structural biology of hendra and nipah virus W protein with host 14 3 3 proteins - Mikayla MH Hoad